On wine version 1.5.24, in Fedora 17 64 bit.
I'm able to run Dungeons and Dragons Online with minimal problems.
One is problems with my in-game keymapping. After I update the keymapping it's not persistent between sessions, or even character changes; This means every time I change characters or log out and back in again, I have to reset my keymapping by hand. For some inexplicable reason, the game loses 3 of my main 0-9 hot keys on each reset. It's a bit of a pain to map them over and over.
I've tried getting the keymapping just the way I wanted, backing the file up while the program is still running and hand copying the backup after disconnect and it still occurs. It also occurs if I change ownership/group to root and removing write access after setting up the hotkeys.
I've updated my locate database and confirmed there are no additional ddo.keymap files anywhere else on the system...I've unlinked and relinked the My Documents symlink in the wine install that points to my linux Documents directory. All edits appear to be occurring on the expected document as the timestamp changes when I update the in game settings.