Hi,
I just tried to get Blood 2 running on my Crunchbang Machine with WineHQ 1.0.1. I didn't encounter any problems during the intallation. But when I started the installed game some issues occured.
1st: When I'm in the configuration menu and try to change the keyboard settings, the ENTER-key stayes pressed constantly so that I can't change the key mappings as I'd wish to.
2nd: When I start playing, there are hardly any textures so that almost all the game's objects (people, interior of the tube...) are white.
3rd: When the first person mode starts, I am not able to control the movements, instead the player is always looking at the ceiling and keeps shooting.
What am I doing wrong here? Did I miss any wine specific configurations?
Problems with Blood 2 - The Chosen
It looks like all of your issues are reported as associated bugs in the AppDB entry for Blood 2, but the app is nonetheless reported as Silver with a more recent version of Wine than you are using (although there are no reports for the current version, which might be further improved. Or indeed, might not, but likely is
).
I would check the AppDB and Bugzilla for tips, and I would upgrade Wine.

I would check the AppDB and Bugzilla for tips, and I would upgrade Wine.