I use Wine mostly to run Adobe Flash CS5.5 on Ubuntu 24.04. When I first installed Flash it was horribly slow, almost unusable. I installed a few packages with Winetricks and that fixed it:
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winetricks atmlib gdiplus msxml6 mfc42
This was fine for a few weeks. This morning though, I turn on my computer and the slowness is back. I tried re-installing those things with winetricks but it just says they're already installed. I tried making a new wineprefix (even a 32-bit one) and reinstalling Flash, reinstalling the winetricks packages. No improvement.
When I installed Wine a few weeks ago (on a fresh Ubuntu 24.04 install), I did it using
these instructions. I think I'm on wine-devel, because wine-stable wasn't available on Noble, from what I could tell. wine --version returns 9.21 right now (I updated this morning through the Ubuntu software updater, after noticing the slowness in Flash, in case it fixed it).