Software will not run on WINE 7.5, WINE 6.0.2

[lukesoft76]

I have two debian systems (both 64bit and multi-arch enabled!).
One is a i5 based server with 64GB of RAM and an IGPU running a bookworm with WINE 7.5.
The other is a core 2 duo based server with 4GB RAM and a NVIDIA GPU running a debian buster with WINE 6.0.2
Within the bokworm system, the program is dieing with a "0104:err:seh:call_stack_handlers invalid".

I degraded the bookworm system to WINE staging 6.0.2 and restarted the program but is also dies.

So here is my question:
Why does the program work on the buster and not on the bookworm with degraded WINE?

Are there any issues related to the GPU?
Are there any issues related to the amount of memory?
How can i use the debugging to find more hints what is going wrong? (I have read the debugging wiki but even with relay it justs states "0104:err:seh:call_stack_handlers invalid" but wrangeld in a lot of unnecessary log output.)

Are there any preconditions that i might look at which might not be satisfied?
Any hint or help appreciated!

[lukesoft76]

Another idea:
The software needs .net version 4.5.
Might it be that the problems arise from Gecko or Mono libraries?

Does it make sense to install .net version 4.5 directly in WINE?