I am running Wine without X or Fonts under CEntOS6.3 32bit.
I did the build like this...
yum install flex
yum install bison
./configure --without-x --without-freetype
make <===== This took a while

make install
winecfg
My application sees the serial port and in my case is able to tell when the CTS / RTS pins are high or low.
I wrote my software to do this.
However I cannot get characters in.
Since then, I have tried everything ...
1. Create the com1, com2 etc, symbolic links to the ttyS0, ttyS1 devices.
2. Change the mode of the ttyS0, ttyS1 devices.
3. Change the mode of the /dev path (not recommended)
4. Add all users to the dialout group
5. Added entries to the emulated registery file
6. Added entries to an (initially non-existant) wine.conf file
7. Added entries to win.ini
Now I must admit that wine will complain when my application runs,
it is a console application but it still tries to create a icon for the
taskbar, this does not stop the launch process.
Other than that EVERYTHING else works except the serial
components.
Thanks for any help.