err:winediag:X11DRV_WineGL_InitOpenglInfo Direct rendering is disabled, most likely your OpenGL drivers haven't been installed correctly (using GL renderer "Gallium 0.4 on ATI RV350", version "1.4 (2.1 Mesa 8.0.4)")
This is terminal output when trying to start a game. Linux native games work fine, like tuxracer etc.
You can try reinstalling your graphics driver, and make sure you have the necessary 32 bit parts, but depending on what you are trying to play, the open source driver may simply be inadequate.