I'm trying to run Mathcad Prime 8.0.0.0 on Arch Linux 5.18.5 with Sway (Wayland) as the window manager. I downloaded the Mathcad installer from the vendor's website.
Using Wine version 7.11, I started the installer:
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wine start pim_installmgr_mathcad.exe
The installation of Mathcad including .NET Framework 4.8 completed successfully:
With pacman, I installed wine-mono 7.3.0.
I got seemingly closest to running Mathcad with this command
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env WINEPREFIX="/home/mb/.wine" xhost +si:localuser:root; sudo wine /home/mb/.wine/drive_c/Program\ Files/PTC/Mathcad\ Prime\ 8.0.0.0/MathcadPrime.exe
The output of the program to stdout and stderr is here. Its last lines are
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wine: Unhandled page fault on write access to 00000001802E3892 at address 000000025D74199D (thread 0100), starting debugger...
0118:fixme:imm:ImeSetActiveContext (00000000003495F0, 1): stub
0118:fixme:imm:ImmReleaseContext (0000000000010072, 00000000003495F0): stub
0120:err:ole:CoUninitialize Mismatched CoUninitialize
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Unhandled exception: page fault on write access to 0x00000001802e3892 in 64-bit code (0x0000025d74199d).