When trying to run anything that opens a graphics window (basically any game) it will crash and Xorg will spit this out on the terminal (this was an attempt to run Half-Life):
[pqcraft@PQC-PC]:~/Programs/Counter-Strike$ wine hl.exe
wine: Read access denied for device L"\\??\\Z:\\", FS volume label and serial are not available.
steamservice.cpp (229) : Assertion Failed: BOpenService failed (1060)
XIO: fatal IO error 9 (Bad file descriptor) on X server ":0"
after 187 requests (186 known processed) with 0 events remaining.
X Error of failed request: BadWindow (invalid Window parameter)
Major opcode of failed request: 10 (X_UnmapWindow)
Resource id in failed request: 0x3600001
Serial number of failed request: 300
Current serial number in output stream: 309
I have no idea what that means but I suspect it has something to do with my graphics drivers as I changed over from 'rocm-dkms' to the Oibaf drivers so that I could use kernel 5.12.2 (it wouldn't compile on anything higher than the 5.8 kernels). Native Linux games/ports of games such as CS:GO and Minecraft do not do this though and this is why I suspect that this is an issue with wine. I made a bug report here: https://bugs.winehq.org/show_bug.cgi?id=51118