Errors regarding Mono and the DotNet framework

[explodersname]

I am having errors running applications that use the dotnet framework.
Here is the output of running an application that requires it.
0009:err:mscoree:LoadLibraryShim error reading registry key for installroot
Failed to run module constructor due to (null) assembly:C:\windows\mono\mono-2.0\lib\mono\4.5\mscorlib.dll type:TypeInitializationException member:(null)
Hope someone could help!

[spoon0042]

Have you tried a fresh wineprefix? dotnet stuff can be finicky and things can get screwed up. Up-to-date wine and winetricks would be the next thing to check, as well as mentioning any specific program you're having an issue with.