Hello,
Why should we make a separate prefix for any Program, when we can make separate profiles with separate dll-overrides for different programs in winecfg?
A) Most of the time it is enough just to make a separate profile in winecfg and no separate prefix is necessary.
B) Often a separate profile is not enough an we must make a separate prefix.
C) It is very seldom enough just to make a separate profile for a program. Most of the time we need a separate prefix for each program.
Thank you.
prefix vs. profile in "winecfg App Tab"
Re: prefix vs. profile in "winecfg App Tab"
It depends. 
To be safest you may want to use individual prefixes to prevent the chance of somehow screwing up the prefix for other apps. Also if you intend to "experiment" you'd probably want to avoid that risk. On the other hand if it's just a dll override or two or a graphics setting or windows version it may not be worth the effort. On the other other hand disk space is cheap these days.
Do whatever works for you. One note I can think of is if you're installing any dotnet version with winetricks since the recommendation for that is to make a fresh prefix since it's a major change and can mess things up. You should be able to use the same prefix for other apps needing the same dotnet version though.
To be safest you may want to use individual prefixes to prevent the chance of somehow screwing up the prefix for other apps. Also if you intend to "experiment" you'd probably want to avoid that risk. On the other hand if it's just a dll override or two or a graphics setting or windows version it may not be worth the effort. On the other other hand disk space is cheap these days.
Do whatever works for you. One note I can think of is if you're installing any dotnet version with winetricks since the recommendation for that is to make a fresh prefix since it's a major change and can mess things up. You should be able to use the same prefix for other apps needing the same dotnet version though.
