Firstly, I have to say Wine is WONDERFUL!
On my Gentoo box, Hitman 2 : Silent Assassin ran really well. So does Contracts but the problem is that the mouse clicks are not detected by the game.
All suggestions are welcome.
Thanks
Hitman 3 : Contracts - Mouse button problem
The workaround described in http://bugs.winehq.org/show_bug.cgi?id=21158 should do the trick.